Your Access Hub

  • Hub Counselors provide assistance with insurance and/or payment issues.
  • Reimbursement support and patient assistance programs are available.


  • *Copay Terms and Conditions:
  • Program is valid for patients with commercial or private insurance
  • Must be a US resident
  • Not valid for patients insured by a federal or state government-funded health plan, including Medicare, Medicare Advantage, Medicaid, and TRICARE
  • Void where the program is prohibited by law
  • Not valid for uninsured patients
  • Program does not replace prescription drug coverage or insurance and is not intended to substitutefor coverage
  • Retrophin reserves the right to terminate or modify this program at any time without notice

Getting THIOLA EC® (tiopronin) tablets is simple through the Total Care Hub. Download the enrollment form now and talk to your doctor about getting started.


Your Delivery Hub

  • Prescription tablets will be delivered directly to your doorstep—avoiding trips to the pharmacy.
  • Notifications to help you plan ahead and manage your refills so you never run out of medication.

Your Support Hub

  • Hub Counselors: Dedicated to providing live, on-demand support to answer questions and help you stay on track with your THIOLA EC treatment.
  • Pharmacists: 24/7 access to THIOLA EC Total Care Hub pharmacists to answer your questions about THIOLA EC.
  • Clinical Nurse Coordinators: Specialized nurses trained to help support you throughout your treatment and provide disease education.

Your Education Hub

  • Receive brochures with updates and information about your treatment.
  • Information and invitations to live patient events.

Contact the Total Care Hub 24 hours a day, 7 days a week, at 844-4-THIOLA (844-484-4652)


Important Safety Information

What is THIOLA EC® (tiopronin) delayed-release tablets?

THIOLA EC delayed-release tablets is a prescription medicine. It is used in combination with high fluid intake, alkali (low acid), and dietary changes to help prevent the formation of one type (cystine) of kidney stones in certain adult and pediatric patients that weigh at least 44 lbs (20 kg) and who do not respond to these measures alone.

Who should not take THIOLA EC?

THIOLA EC should not be taken if you:

  • are allergic to THIOLA EC, or any of the ingredients in THIOLA EC.

What should I tell my doctor before taking THIOLA EC?

THIOLA EC may not be right for you. Before taking THIOLA EC, tell your doctor about:

  • all health conditions you may have and any medications you may be taking.
  • if you are pregnant or plan to become pregnant.
  • if you are breastfeeding or plan to breastfeed.

What should I avoid while taking THIOLA EC?

You should avoid drinking alcohol 2 hours before and 3 hours after taking THIOLA EC.

What are possible side effects of THIOLA EC?

Serious Side Effects: THIOLA EC can cause proteinuria (high amounts of protein in urine), including serious kidney problems, and hypersensitivity reactions (including fever, rash, joint pain and enlarged or swollen lymph nodes).

Most Common Side Effects: Nausea, diarrhea or soft stools, sores in the mouth, rash, fatigue, fever, muscle or joint pain, high amounts of protein in urine, vomiting.

These are not all the possible side effects of THIOLA EC. Call your doctor for medical advice about side effects.

You may report negative side effects to Retrophin® Medical Information at 1-877-659-5518, or to the FDA at 1-800-FDA-1088 or

Please see full THIOLA EC Prescribing Information.